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It also modulates pineal gland function and circadian biology—restoring nighttime melatonin release and normalizing disrupted sleep–wake rhythms in older humans and animals

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The use of mouse embryonic fibroblast (MEF) from single or double KO mice for arrestins 2 and 3 revealed that DOR desensitization induced by DPDPE relies predominantly on arrestin 3 expression suggesting a preferential interaction between DOR and this arrestin isoform (Qiu et al., 2007)