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This includes their capacity for immunosuppression, inhibition of the TGF-β1 pathway and mitigation of hypoxia and oxidative stress[40]

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In the natural aging + FOXO4-DRI group, mice received intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days during the same period, followed by tissue collection