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FSHR and LHR are both G-protein coupled receptors (GPCRs) that transmit the intracellular cascade via adenylate cyclase activity, cAMP accumulation, with subsequent activation of PKA, which then phosphorylates the transcription factor CREB (cAMP response element binding protein)

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VaitiekusDMuckieneGVaitiekieneASereikaiteLInciuraiteRInsodaiteRet alHFE Gene Variants’ impact on anthracycline-based chemotherapy-induced subclinical cardiotoxicity